medRxiv PreprintsInternational28 October 2026
Infectious disease outbreaks among hospitalised neonates in low- and middle-income countries: a systematic review.
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Neonatal unit outbreaks are frequent in low- and middle-income country (LMIC) hospitals, but consolidated data to guide outbreak investigation, infection prevention and control, and treatment strategies remain limited. We conducted a systematic review describing pathogen profiles, antimicrobial resistance (AMR) patterns, outbreak sources, and the application of whole-genome sequencing (WGS) in neonatal outbreak investigation. Reports of bacterial or fungal outbreaks in LMIC neonatal units published between 1 January 2015 and 31 July 2025 were identified from EMBASE, Global Health, PubMed, Scop
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