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medRxiv PreprintsInternational2 November 2026

Incremental value of bilateral ankle-brachial index for ten-year heart and cerebrovascular mortality prediction: an exploratory temporal benchmark in NHANES

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Background: Ankle-brachial index (ABI) is associated with systemic vascular disease, but its incremental predictive value depends on the clinical comparator, endpoint and validation design. Objective: To test whether a bilateral ABI feature block improves a nonlaboratory clinical benchmark for ten-year death from diseases of the heart or cerebrovascular disease, and whether a limited nonlinear learner improves the same chronological evaluation. Methods: We rebuilt public NHANES 1999-2004 examination data linked to the 2019 public-use mortality file. Adults aged at least 40 years with bilateral
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