Incremental Prognostic Value of Regional Myocardial Flow Reserve Beyond Global Flow and Perfusion: REFINE PET

Background: The incremental prognostic value of regional myocardial flow reserve (MFR) assessed by positron emission tomography (PET) myocardial perfusion imaging (MPI) beyond global MFR remains unclear. We sought to evaluate the prognostic value of regional MFR in the international multicenter REFINE PET registry. Methods: This retrospective multicenter cohort study included 35,391 patients from 13 sites in the international REFINE PET registry who underwent rubidium-82 (82Rb) and 13N-ammonia(13NH3) PET MPI. Abnormal MFR was defined as 90 days), and hospital admission for unstable angina. Res

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