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medRxiv PreprintsInternational1 November 2026

Implementing blended cognitive behavioral therapy for severe fatigue in routine hospital care for diffuse glioma patients: a qualitative study

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Abstract Background: Severe fatigue is common in diffuse glioma patients and can persist after tumor treatment. Fatigue-tailored blended cognitive behavioral therapy (bCBT) has been shown to reduce severe fatigue in glioma patients. This study aimed to identify barriers and facilitators to implementing bCBT for severe fatigue in glioma care and to develop implementation strategies tailored to the neuro-oncology context. Methods: A qualitative study was conducted among healthcare professionals involved in glioma care, including neurologists, nurse practitioners, and (neuro)psychologists. Semi-s
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