Hypoxic Burden Predicts Symptomatic but Not Sleep Architecture Response to CPAP Therapy in Obstructive Sleep Apnea

The apnea-hypopnea index (AHI) remains the standard metric for assessing obstructive sleep apnea (OSA) severity, although it does not fully capture the physiological consequences of respiratory events. Hypoxic burden (HB), which integrates the frequency, depth, and duration of oxygen desaturations, has been proposed as a more comprehensive measure of OSA-related hypoxic stress. This study compared the prognostic value of HB and AHI for subjective and objective treatment outcomes in patients undergoing continuous positive airway pressure (CPAP) therapy. Data from 412 patients with OSA who under

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