Hospitalized patients lack pathogen-specific comorbidity signatures: general vulnerability and case fatality drive differences in mortality

Objectives This study aimed to investigate pathogen-specific prevalence, 30-day mortality, and host factors associated with infection in a large tertiary-care hospital cohort, and to evaluate whether comorbidity patterns and machine-learning models can predict individual outcomes. Methods We conducted a 39-month retrospective cohort study of 16,282 hospitalized patients with positive bacterial cultures at a tertiary-care university hospital. Cox proportional hazards models identified mortality risk factors. Comorbidity-pathogen associations were examined using logistic regression. Five machine

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