High-frequency EEG activity moderates the association between amyloid burden and tau in cognitively normal adults

Background: Resting electroencephalogram (EEG) may capture early excitatory-inhibitory (E-I) imbalance in Alzheimer's disease, but its relationship to beta-amyloid and tau in cognitively normal adults is unclear. Methods: We analyzed resting-state EEG from 24 older adults, 21 cognitively normal (13 beta-amyloid-negative, 8 beta-amyloid-positive) and 3 with MCI/AD (all beta-amyloid-positive), with beta-amyloid positron emission tomography (PET); 20 of the cognitively normal adults also had tau PET. Four parietal measures related to E-I balance and excitability (periodic gamma power, alpha-gamma

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