Hierarchy of immunogenicity of Plasmodium falciparum merozoite antigens and vaccine candidates in first human infection

Background: Merozoite antigens are targets of acquired immunity and are promising targets for next-generation malaria vaccines and serosurveillance tools. However, the immunogenicity of each antigen and their induction of antibodies following infection remains unclear, impacting vaccine design, antigen selection in serosurveillance, and our understanding of naturally-acquired immunity. Methods: To address this, we assessed IgG and IgM responses to whole merozoites and individual merozoite antigens in 81 malaria-naive adults who experienced a blood-stage P. falciparum Controlled Human Malaria I

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