Head-to-Head Comparison of Flortaucipir and MK6240 tau-PET to Detect Subtle Objective Cognitive Impairment in Clinically Unimpaired Individuals

Background and Objectives: Tau-PET is associated with subtle objective cognitive impairment (SOCI) in clinically unimpaired (CU) individuals, but whether the spatial patterns and strengths of these associations differ across tracers remains unclear. We performed a head-to-head comparison of [18F]MK6240 and [18F]flortaucipir to investigate their associations with SOCI in CU individuals. Methods: We cross-sectionally assessed CU participants from the HEAD study who underwent both tau-PET scans. Linear regressions examined associations between domain-specific cognition and tau burden using standa

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