Greater than the sum of its parts: A novel psychiatric multimorbidity metric applied to rare disease

Importance: Rare genetic syndromes are often drivers of complex multimorbidity. However, current methods consider multimorbidity as the sum of chronic diagnoses, which does not account for subthreshold impairment. Objective: To develop a quantitative multimorbidity score (MMS) for rare genetic syndromes that summarizes the neurodevelopmental and psychiatric multimorbidity landscape, including subthreshold symptoms, using 3q29 deletion and 3q29 duplication syndromes as hallmark examples. Design: We developed a multimorbidity metric and applied it to cross-sectional data. Remote phenotyping from

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