Greater Stress Response Network (SRN) Connectivity is Associated with Higher Worry in Men and Women Especially in Later Life

Background: Late-life anxiety is common and disabling, with pathological worry as a core feature. The Stress Response Network (SRN: amygdala, bed nucleus of the stria terminalis, paraventricular nucleus), which modulates threat and stress reactivity, and its interaction with the Executive Control Network (ECN), anchored by the dorsolateral prefrontal cortex, which supports emotional regulation via top-down cognitive control, may underlie individual differences in worry severity. We hypothesize higher SRN connectivity to be associated with greater worry severity and that this relationship may b

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