Genome-wide meta-analysis of pilonidal sinus disease and its genetic overlap with hidradenitis suppurativa, hair patterning and adiposity

Pilonidal sinus disease (PSD) is a common, recurrent inflammatory disease of the natal cleft that clusters in families, but few genetic risk loci are known and its relationship with hidradenitis suppurativa (HS), acne and obesity is unclear. We meta-analysed public genome-wide summary statistics from the Million Veteran Program, UK Biobank, FinnGen and Genes & Health (7,868 cases and 1.6 million controls from four ancestry groups). Of 25 genome-wide significant loci outside the MHC, 19 were novel and 21 remained significant after correction for test-statistic inflation. Liability-scale SNP her

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