medRxiv PreprintsInternational28 October 2026
Gastrointestinal medication use patterns and incident depressive symptoms among adults aged 50 years or older: a prospective multicohort study
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Background: Depressive symptoms contribute substantially to disability and loss of independence in later life, and gastrointestinal illness frequently co-occurs with affective vulnerability. However, evidence linking gastrointestinal medication use to subsequent depressive symptoms remains largely confined to single countries and cross-sectional assessments. We investigated whether baseline gastrointestinal medication use and longitudinal two-wave medication-use patterns are associated with incident depressive symptoms across three prospective ageing cohorts. Methods: We analysed community-dwe
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