Examining the Etiological Specificity of Genetic Risk for Alcohol Use Disorder and Alcohol Consumption through Symptom-Level Mediation Analyses

Introduction. Polygenic scores (PGSs) for alcohol use disorder (AUD) may capture genetic liability related to alcohol consumption as well as broader transdiagnostic traits, including impulsivity, aggression, and neuroticism. However, the extent to which these traits account for associations between an AUD PGS and the presentation of AUD symptoms remains unclear. Thus, to better understand the genetic influences captured by an AUD PGS, the present study used mediation analyses to examine whether these transdiagnostic traits differentially mediate the relations between PGSs for AUD and individua

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