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medRxiv PreprintsInternational28 October 2026

Evaluating ChatGPTs Responses to Chiropractic Patient Questions: A Comparative Study

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Background Large language models (LLMs) are used at an increased frequency by patients to answer health related questions. Prior studies have evaluated LLMs and their performance with musculoskeletal (MSK) and spine domains, but have not been used to evaluate chiropractic-relevant content. Objective To evaluate ChatGPT responses to commonly asked chiropractic patient questions for concordance with chiropractic clinical practice guidelines. Methods Thirty questions addressing low back pain, neck pain, and chronic musculoskeletal pain were developed based on current U.S. chiropractic clinical pr
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