Establishing a blood-stage controlled human malaria infection model with Plasmodium falciparum in healthy semi-immune Tanzanian adults

Controlled human malaria infection (CHMI) studies are a critical tool for the assessment and down-selection of potential malaria interventions, allowing detailed characterisation and understanding of host-parasite responses to inform both malaria vaccine and antimalarial drug development in humans. Blood-stage CHMI offers a specific means for proof-of-concept testing of blood-stage malaria vaccines, bypassing the pre-erythrocytic stages of malaria infection. Here, we establish a blood-stage CHMI model in an endemic region in a clinical study involving 12 healthy semi-immune male adult particip

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