Enhancing deep sleep with auditory stimulation to boost cognitive training responsiveness in people with Parkinson's disease and mild cognitive impairment: Rationale and design of the double-blind randomized controlled trial PD-CogT-Sleep

Background: Cognitive training (CogT) is an established non-pharmacological intervention for people with Parkinson's disease (PD) and mild cognitive impairment (PD-MCI). However, overall effects on cognitive outcomes are small to moderate and interindividually highly heterogeneous. Sleep -especially deep sleep- could be an important determinant of CogT responsiveness in PD, and may have beneficial effects on PD pathophysiology. Therefore, the enhancement of deep sleep by phase-targeted auditory stimulation (PTAS) could strengthen the effects of CogT on cognitive symptoms and counteract disease

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