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medRxiv PreprintsInternational3 November 2026

Elevated Maternal Glycated Albumin is Associated with Large for Gestational Age Infants: Results from a Prospective Longitudinal Study

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Aims/hypothesis Glycated albumin (GA) has been shown to be a moderate predictor of gestational diabetes mellitus (GDM), while evidence supporting its role in predicting adverse pregnancy outcomes remains limited. Here, we aimed to perform a comparative study of GA and haemoglobin A1c (HbA1c) for predicting GDM and large-for-gestational-age (LGA) infants in a prospective cohort. Methods We developed a rapid liquid chromatography-tandem mass spectrometry method for measuring site-specific albumin glycation. GA was quantified at two glycation sites, GA (KQT) and GA (KLV), as well as their sum, GA
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