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medRxiv PreprintsInternational6 November 2026

Electric and Magnetic Source Imaging in Epilepsy: Anatomical Insights from Realistic Simulations

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Neurosurgery is an effective treatment for drug-resistant epilepsy (DRE), but its success depends on the accurate delineation of the epileptogenic focus, approximated noninvasively by electric and magnetic source imaging (ESI/MSI) of high-density electroencephalography (HD-EEG) and magnetoencephalography (MEG). These modalities have distinct sensitivity profiles; consequently, epileptiform activity detected by one modality may remain undetected by the other. However, the implications of these differences for spike detectability and localization accuracy, and the added value of combined electro
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