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medRxiv PreprintsInternational2 November 2026

Effect of Intensity Discretization on Radiomic Features in En Face EDI-OCT of Choroidal Nevi

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Background/Objectives: Intensity discretization influences radiomic measurements, but its effects in optical coherence tomography (OCT) of choroidal lesions remain insufficiently characterized. We evaluated fixed bin width (FBW) and fixed bin number (FBN) strategies with different parameters to inform discretization choices for en face enhanced-depth imaging OCT (EDI-OCT) of stable choroidal nevi. Methods: Ninety-three original-domain radiomic features were extracted from 64 eyes across 11 discretization settings (FBW 2 - 64; FBN 8 - 64). We assessed feature values, eye rankings, observer repr
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