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medRxiv PreprintsInternational29 October 2026

Effect of home blood pressure monitoring on major adverse cardiovascular events and all-cause mortality: results from the VA HOMESTEAD study

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Importance: Home blood pressure monitoring (HBPM) has been shown to lower blood pressure (BP) in randomized trials, however its real-world effect on clinical outcomes is not known. Objective: To determine the association between HBPM and clinical outcomes including cardiovascular events and mortality. Design: Target trial emulation employing matched cohorts with index-date follow-up. Setting: Veterans Health Administration (VHA) telehealth program. Participants: Eligible Veterans had uncontrolled BP (defined as a systolic BP >140 mmHg) at a primary care visit within VHA, with a systolic BP >14
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