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medRxiv PreprintsInternational28 October 2026

Early Lymphocyte Dynamics and Subsequent Cancer Therapy-Related Cardiac Dysfunction in Patients Receiving Anthracycline Therapy

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Background: Whether early treatment-related lymphocyte dynamics are associated with cancer therapy?related cardiac dysfunction (CTRCD) after anthracycline therapy is uncertain. This study sought to determine the association between early change in lymphocyte and subsequent CTRCD and to assess its incremental value beyond clinical characteristics. Methods: We retrospectively studied anthracycline-treated adults in the Medical Information Mart for Intensive Care IV (MIMIC-IV) database with linked echocardiographic data (MIMIC-IV-Echo). The primary exposure was relative change in lymphocyte perce
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