medRxiv PreprintsInternational5 November 2026
Door-to-Valve Time and Clinical Outcomes in Acute Decompensated Severe Aortic Stenosis: Systematic Review and Meta-Analysis
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Background: Acute decompensated aortic stenosis (ADAS) carries high mortality, but the optimal timing of valve intervention is unknown. Objective: To assess the association between time to valve intervention (transcatheter aortic valve replacement [TAVR] or balloon aortic valvuloplasty [BAV]) and clinical outcomes in ADAS. Methods: Embase, Ovid MEDLINE and CENTRAL were searched to May 15, 2026. Hazard ratios (HRs) for delayed versus earlier intervention were pooled using random-effects models with modified Hartung-Knapp inference. Unadjusted short-term mortality risk ratios (RRs) were pooled u
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