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medRxiv PreprintsInternational28 October 2026

Diurnal Glycemic Redistribution in Obesity Despite Matched Mean Glucose

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Background and Aims: Mean glucose and HbA1c reflect average glycemic exposure but do not capture its 24-hour distribution. When average glycemia is comparable, whether obesity is associated with a distinct temporal glucose pattern remains unclear. We compared continuous glucose monitoring (CGM) profiles in lean adults and adults with obesity matched for mean glucose. Methods: In a cross-sectional AI-READI analysis, lean adults (BMI 18.5 to =30 kg/m2) by recruitment center and clinical group, with calipers for age, mean glucose and glucose standard deviation. CGM profiles were compared by clock
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