Distinct Biomarker Signatures of CMR-Defined Myocardial Remodeling in Moderate Aortic Stenosis

Background: Moderate aortic stenosis (AS) is associated with adverse outcomes, yet the myocardial response to pressure overload varies substantially between patients and is incompletely reflected by valve hemodynamics. We aimed to determine whether circulating biomarkers of myocardial stress, injury, and fibrosis associate with cardiac magnetic resonance (CMR)-defined myocardial remodeling in moderate AS. Methods: Eighty-nine patients with moderate AS prospectively underwent CMR (cine imaging, T1 mapping, extracellular volume fraction [ECV], late gadolinium enhancement [LGE]) with concurrent m

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