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medRxiv PreprintsInternational6 November 2026

Digital Twin-Based Risk Stratification Integrating Aortic Shape and Wall Mechanics in Acute Uncomplicated Type B Aortic Dissection

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Objective This study evaluated whether patient-specific digital twins integrating 3D aortic anatomy and structural wall stress could identify patients with acute uncomplicated type B aortic dissection (AUTBAD) at high risk for adverse aortic events. Methods We analyzed CTAs from 50 patients extracted from a 400 AUTBAD patient database treated with optimal medical therapy from 1999-2025. Digital twin models were constructed, and statistical shape modeling and reduced-order fluid-structure interaction analysis were performed. Anatomic shape and biomechanical stress data were integrated into mode
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