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medRxiv PreprintsInternational3 November 2026

Diagnostic Feature Associations in Atypical Parkinsonian Disorders: A Survey of Movement Disorders Specialists

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Objective: For the atypical parkinsonian disorders (APDs), including dementia with Lewy bodies (DLB), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD), accurate antemortem diagnosis remains clinically challenging because of overlapping features, phenotypic heterogeneity, and limited definitive biomarkers. Consensus diagnostic criteria are complex and may not reflect how clinicians operationalize diagnostic reasoning in practice. Methods: We surveyed movement disorders specialists regarding diagnostic implications of 32 clinical features,
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