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medRxiv PreprintsInternational5 November 2026

Development and psychometric evaluation of the Severity of Myalgic Encephalomyelitis Scale (SoMES) and the Myalgic Encephalomyelitis Occupational Status Scale (MEOSS)

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Objective: To develop and psychometrically evaluate two new brief assessments measuring disease severity (the Severity of ME Scale, SoMES) and occupational status (the ME Occupational Status Scale, MEOSS) in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) Methods: Draft SoMES and MEOSS were co-produced from relevant literature and lived experience. An online survey completed by adults with ME/CFS and was repeated two weeks later to assess reliability. The SF-36 (physical function) assessed criterion-related validity (Spearmann correlations) and discriminant validity (Kruskal-Wallis
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