Design and evaluation of probe-capture sequencing for clinical Neisseria gonorrhoeae specimens

Characterizing the molecular epidemiology of Neisseria gonorrhoeae is essential for understanding disease burden, elucidating transmission dynamics, and informing clinical decision-making and public health interventions. Given that routine, culture-independent diagnostics rapidly and sensitively detect this difficult-to-cultivate pathogen, aligning genomic surveillance with these workflows is necessary to understand its epidemiology and evolutionary dynamics. To address this challenge, we investigated the utility of probe-capture sequencing to selectively enrich for pathogen-specific DNA durin

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