Dermal macrophages acquire a TREM2-anchored profibrotic state in antiphospholipid syndrome that is reflected in the circulation

Antiphospholipid syndrome (APS) is a systemic autoimmune disease best known for thrombosis and obstetric morbidity. APS is sometimes also characterized by chronic microvascular disease, which can impair renal and other organ function. Skin offers an accessible window into the tissue mechanisms underlying such manifestations. Our previous single-cell analysis of skin biopsies from three patients with established microvascular disease focused on dermal endothelial cells and implicated a Hippo-YAP1-CCN2 axis in vascular pathology. Here, we expanded single-cell profiling to dermal tissue from 30 p

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