Deep immune cell phenotyping predicts influenza vaccine immunogenicity in HCT recipients

Annual influenza vaccination is recommended after allogeneic hematopoietic cell transplantation (HCT), but antibody responses vary widely. We asked whether pre-vaccination immune-cell composition predicts the antibody response beyond baseline titers and clinical factors. We studied the first vaccination season of 260 participants in 2 multicenter phase 2 trials of high- versus standard-dose influenza vaccine, 1 pediatric and 1 adult, and held out for validation 74 second-season episodes from participants who re-enrolled the following year. Thirty-marker mass cytometry measured blood cell compo

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