Cross study transfer of vascular transcriptomic classifiers in seven public cohorts

Strong discrimination within a vascular transcriptomic study may not transfer across clinical endpoints, tissue compartments or assay processing. We evaluated seven public Gene Expression Omnibus datasets containing 294 deposited observations, including repeated lesion segments. Four conventional classifiers and a prior-only control underwent nested validation in 48 abdominal aortic aneurysm samples, followed by external evaluation under three preprocessing configurations. Source-rank L1 logistic regression achieved an area under the receiver operating characteristic curve of 0.947; external v

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