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medRxiv PreprintsInternational5 November 2026

Cost Analysis of Vasopressin Use in Septic Shock and Predictive Performance of GOSSIS in ICU Mortality

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Background: Vasopressin is a commonly used adjunctive therapy in the management of septic shock. While vasopressin may provide clinical benefits, at times its acquisition cost has risen to being substantially more expensive than other second-line vasopressors such as epinephrine, phenylephrine, or dopamine. Additionally, mortality prediction tools such as the Global Open-Source Severity of Illness Score (GOSSIS) have emerged as a valuable resource to guide resource allocation in critical care. This study aimed to evaluate the healthcare costs associated with vasopressin use and assess the pred
Source: medRxiv Preprints
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