Cortical Thinning in Adults with Prader-Willi Syndrome: Distribution Across Functional Networks and Associations with BMI and the GH/IGF-1 Axis

Prader-Willi syndrome (PWS) is a rare neurogenetic disorder associated with neuropsychiatric, metabolic, endocrine, and physical abnormalities. Although previous neuroimaging studies have identified regional gray matter alterations, cortical thickness (CT) abnormalities and their distribution across large-scale functional brain networks remain poorly characterized in adults with PWS. We investigated cortical morphology in 23 adults with PWS and 22 age- and sex-matched healthy controls who underwent structural MRI. Cortical reconstruction and surface-based morphometric analyses were performed u

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