medRxiv PreprintsInternational6 November 2026
Cognitive Performance in Prodromal Neuronal α Synuclein Disease
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Importance: Cognitive abnormalities may emerge during prodromal neuronal a-synuclein disease (NSD), but their domain specificity and longitudinal course are uncertain. Objective: To characterize baseline cognition and longitudinal change in prodromal NSD compared with healthy controls, NSD-negative genetic carriers, and sporadic Parkinson disease (PD). Design: Longitudinal cohort study using Parkinson's Precision Medicine Initiative (PPMI) data, with first visits from July 2010 through April 2026 and up to 4 years of follow-up. Setting: Multicenter cohort. Participants: Healthy controls (HC; n
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