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medRxiv PreprintsInternational5 November 2026

Clinician Counseling and Patient Storage and Disposal Practices for Opioids Prescribed for Acute Pain: A Multicenter Prospective Cohort Study

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BACKGROUND: Opioids prescribed for acute pain frequently remain unused, creating opportunities for unintended use, accidental ingestion, or diversion. Little is known about counseling patients receive from prescribers or pharmacists on storage and disposal of opioids. OBJECTIVE: To characterize clinician counseling on opioid disposal and patient-reported storage, use, and disposal practices among opioid-naive patients prescribed opioids for acute pain. DESIGN: Multicenter prospective cohort study with participant recruitment between September 2020 and March 2023. PARTICIPANTS: Opioid-naive pat
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