Clinically Meaningful Cognitive Improvement from Intermittent Neurostimulation of the Nucleus Basalis of Meynert in Parkinson's Disease

Cognitive decline begins in early stages of Parkinson's disease (PD) for many individuals and remains largely untreated. The nucleus basalis of Meynert (NBM), the brain's cortical cholinergic hub, and its lateral efferent fiber bundle degenerate early in PD and are linked to cognitive and cognitive-motor impairment. Pre-clinical evidence indicates intermittent stimulation of the NBM improves cognition. The objective of this study is to establish the feasibility of combined continuous subthalamic nucleus (STN) and intermittent NBM DBS for cognitive impairment in people with PD. Five patients wi

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