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medRxiv PreprintsInternational3 November 2026

Capturing additional variance in impact of adolescent depression from free text: proof of concept and preliminary results

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Depression in adolescents has grown in prevalence in the past decade. Despite indications of differences in symptom presentation, measurement properties, and treatment response between adolescents and adults, research is dominated by adult participants. Qualitative work has identified symptomatic and functional domains important to depressed adolescents and those around them; however, there remains little quantitative evidence of how these domains relate to the functional impact of the disorder. In this preregistered study, we use adolescent self-report (n = 153) and parent-report (n = 106) re
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