Brain-Derived pTau217 and Plasma Proteomic Profiles Across Cognitive and Dementia Groups in Congolese Older Adults

Blood-based biomarkers for Alzheimer disease and related dementias have been validated largely in populations of European ancestry. We characterized plasma proteins in 786 adults aged 65 years or older in Kinshasa, Democratic Republic of the Congo, classified as cognitively unimpaired, mild cognitive impairment, suspected Alzheimer disease, mixed dementia, or vascular dementia. Proteins were quantified with the NULISAseq CNS Disease Panel 120. Sex showed the strongest associations with protein expression, followed by age, whereas APOE {varepsilon}4 carrier status was associated with four measu

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