Biomarkers of ageing and lung function trajectory: a multi-omics study in a UK birth cohort

BACKGROUND: Accelerated biological ageing and cellular senescence are pathogenically implicated in COPD and may represent therapeutic targets. Adverse early-life lung function trajectories offer opportunities to prevent COPD but their relationship with epigenetic and proteomic ageing biomarkers remains unexplored. We investigated using conventional epidemiological and Mendelian randomisation (MR) methods. METHODS: Outcomes were the two lowest of five FEV1 trajectories (Persistently Low and Below Average) previously identified using latent profile analysis (ages 8-30) in the Avon Longitudinal S

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