Atlas-Based MRI Spatial Phenotyping in Pediatric Low-Grade Glioma

Pediatric low-grade gliomas (pLGGs) arise throughout the developing brain, and their anatomic distribution is related to age, molecular subtype, and extent of resection (EOR). In clinical studies, pLGG location is commonly represented by a single manually assigned anatomic category, which does not quantify the full spatial extent of tumors spanning multiple brain regions. We developed and evaluated a reproducible, publicly available pediatric atlas-based framework integrating voxel-wise probabilistic mapping with patient-level atlas-derived spatial features. In this retrospective study, preope

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