Assessment of Dissemination in Time in Multiple Sclerosis Using a Single 3D T2-FLAIR magnetic resonance imaging Radiomic Signature

Background: In multiple sclerosis (MS), dissemination in time (DIT) is an important component of demonstrating disease activity and establishing the chronology of lesion development. DIT is routinely assessed from contrast-enhanced or follow-up magnetic resonance imaging (MRI). Although proved useful, these methods are not without caveats motivating alternative approaches to study lesion chronology. We investigated whether single T2-FLAIR MRI contains sufficient information to distinguish temporally distinct MS lesion categories using radiomic features. Methods: In a retrospective longitudinal

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