medRxiv PreprintsInternational5 November 2026
Anticholinergic Medications and Health in Adults with Autism or Intellectual Disability
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Objective: Contributors to autistic adults' elevated risk for negative aging-related outcomes, including Alzheimer's disease and related dementias (ADRD), falls, and mortality remain underexplored. One candidate factor is exposure to medications with anticholinergic (AC) effects. Thus, this study assessed prevalence of medications with AC effects, and their associations with ADRD, falls, and mortality across four groups: autism-only, autism+intellectual disability (ID), ID-only, and controls. Methods: We conducted a retrospective cohort study of 2017-2019 US linked Medicare and Medicaid claims
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