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medRxiv PreprintsInternational28 October 2026

An electronic frailty index for population-level risk stratification in a large health maintenance organization: A cohort study

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Background. Frailty is a state of decreased physiological reserve and increased vulnerability to adverse outcomes. It can be quantified using the cumulative deficit model, which is defined as the proportion of deficits present from a predefined list of age-related health conditions identified from electronic health record (EHR) data. We developed and validated an electronic frailty index, CeFI, for Clalit Health Services (CHS), Israel's largest HMO. Methods. This retrospective cohort study used de-identified EHR data from 641,748 CHS members aged [≥]65 years on January 1, 2018, randomly spl
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