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medRxiv PreprintsInternational6 November 2026

Additional tuberculosis case detection through repeat household contact investigation at 6 and 12 months: a retrospective cohort study in Kasama, a peri-urban district in Zambia

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Background: Tuberculosis contact investigation (TBCI) facilitates early detection of TB among household contacts. However, evidence on the additional contribution of repeat TBCI in high-burden settings remains limited. We assessed the contribution of repeat TBCI at 6 and 12 months to TB case detection in Kasama District, Zambia. Methods: We conducted a retrospective observational cohort analysis of routinely collected programme data from five purposively selected high-volume TB diagnostic facilities. Household contacts of bacteriologically confirmed TB patients notified between January 2023 an
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