A connection-level genetic atlas of human cortical functional connectivity at rest and during a task

Genetic studies of cortical functional connectivity have analyzed aggregated traits, which fails to show which connections a variant acts on. We present a connection-level genetic atlas: genome-wide association analyses of 64,620 connections among 360 cortical areas in UK Biobank participants of European ancestry at rest (n = 52,983) and during an emotion-processing task (n = 45,010), with replication in an independent sample (n = 15,546). We identified 247 resting and 96 task loci; 193 resting loci were new to fMRI genetics and 112 replicated. Most loci affected connections between networks.

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