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medRxiv PreprintsInternational5 October 2026

UGB-SegNet: Uncertainty-Guided Multi-Scale Attention and Boundary-Aware Learning for Breast Ultrasound Lesion Segmentation

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Accurate breast lesion segmentation in ultrasound is difficult because speckle noise, heterogeneous lesion appearance, and poorly defined margins can obscure clinically relevant boundaries. This work presents UGB-SegNet, an uncertainty-guided breast ultrasound segmentation network that combines four components: multi-scale convolutional block attention (CBAM) at three EfficientNet-B0 encoder stages, a learnable feature pyramid network for adaptive multi-scale fusion, an entropy-guided decoder that routes fine-grained encoder information toward uncertain regions, and a boundary-aware composite
— medRxiv Preprints
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