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medRxiv PreprintsInternational6 October 2026

Right Versus Left Ventricular Myofiber Orientation in Various Congenital Heart Diseases Analyzed with X-Ray Phase-Contrast Tomography

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BACKGROUND: While the systemic right and left ventricles have different functional prognoses, only a limited number of reports have addressed their myocardial architecture. This study analyzed myofiber orientation of human specimens with various congenital heart diseases using X-ray phase-contrast tomography. METHODS: Three specimens of each normal heart, ventricular septal defect, right atrial isomerism, left atrial isomerism, and ventricular inversion were examined. In reconstructed images of both ventricles, the center of the free wall was resliced parallel to the myocardial surface. A myof
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