medRxiv PreprintsInternational16 October 2026
Trends and Disparities in Respiratory Failure Mortality with Co-Listed Atrial Fibrillation and Flutter Among U.S. Adults Aged >= 65 Years, 1999 to 2024, with AAMR Forecasts Through 2035: A CDC Wonder Analysis
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Abstract Background: Respiratory failure (RF) and atrial fibrillation/flutter (AF/AFL) often occur together in older adults, but long-term national mortality trends for the two conditions combined have not been described. We examined trends and disparities in deaths with co-listed RF and AF/AFL among U.S. adults aged 65 years and older from 1999 to 2024, and projected rates through 2035. Methodology: We used the CDC WONDER Multiple Cause of Death database to identify deaths with ICD 10 codes J96 (RF) and I48 (AF/AFL) listed together. Age-adjusted mortality rates (AAMRs) per 100,000 were standa
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