Spatial Neurophysiological Gradients at High Resolution Differentiate Tumor Types in the Human Cortex at the Tumor-Brain Interface

Brain tumors interact with adjacent neural circuits, with tumor infiltration altering neural physiology, and aberrant neuronal activity, in-turn, promoting tumor growth. Due to limited patient numbers, variable recording methods, and tumor heterogeneity, direct evidence of electrophysiologic distinctions between specific tumor types and these interactions in the intact human brain is lacking. Here, we analyzed intraoperative recordings from 100 participants undergoing tumor resection, epilepsy surgery, or movement disorder deep brain stimulator implant surgeries using clinical electrocorticogr

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